2017
Advances in (environmental) exposure modelling: Bridging the gap between research and application. Technical Report
no. Workshop Report No. 35, 2017, ISSN: 2078-7219-35.
Abstract | Links | Tags: 2017, ECETOC, Public Report
@techreport{2017ECETOCGap,
title = {Advances in (environmental) exposure modelling: Bridging the gap between research and application.},
url = {https://www.ecetoc.org/publication/workshop-report-35-advances-in-environmental-exposure-modelling-bridging-the-gap-between-research-and-application-4-5-may-2017-brussels/, Workshop Page
https://www.ecetoc.org/wp-content/uploads/2021/10/ECETOC-WR-35.-Advances-in-environmental-exposure-modelling.pdf, Workshop Report},
issn = {2078-7219-35},
year = {2017},
date = {2017-05-04},
urldate = {2017-05-04},
number = {Workshop Report No. 35},
abstract = {This workshop was held to assess the current status of the science of environmental chemical exposure modelling in order to identify areas for improvement and recommend practical steps to improve the current situation. The workshop was attended by sixty international scientific experts from industry, academia, regulatory agencies and consultancies.
Assessing environmental exposure of chemicals is a challenging but critical part of assessing environmental risk. While there has been a great deal of resource directed towards activities aimed at advancing the use and application of exposure models, this ECETOC workshop provided the opportunity to review the recent advances in exposure models, with a particular focus on the following key themes:
Quantification of uncertainties
Identification of synergies across the different industry sectors and regulatory bodies
Applicability domain challenges
Chemical mixtures
Non-chemical stressors
Both regulatory and research-oriented models were considered within focused syndicate sessions dedicated to various categories of industrial chemicals.
The workshop included an IT Modelling Fair at the end of the first day, where some of the participants demonstrated exposure modelling tools and offered attendees some hands-on experience.
Workshop participants agreed on a number of general principles of best practice in environmental exposure modelling, and some recommendations were identified for practical steps towards improving the use and application of models. These are captured in the workshop report.
This report will be of interest to academic researchers, industrial environmental fate assessors, and regulatory bodies involved in chemical risk assessment.},
keywords = {2017, ECETOC, Public Report},
pubstate = {published},
tppubtype = {techreport}
}
This workshop was held to assess the current status of the science of environmental chemical exposure modelling in order to identify areas for improvement and recommend practical steps to improve the current situation. The workshop was attended by sixty international scientific experts from industry, academia, regulatory agencies and consultancies.
Assessing environmental exposure of chemicals is a challenging but critical part of assessing environmental risk. While there has been a great deal of resource directed towards activities aimed at advancing the use and application of exposure models, this ECETOC workshop provided the opportunity to review the recent advances in exposure models, with a particular focus on the following key themes:
Quantification of uncertainties
Identification of synergies across the different industry sectors and regulatory bodies
Applicability domain challenges
Chemical mixtures
Non-chemical stressors
Both regulatory and research-oriented models were considered within focused syndicate sessions dedicated to various categories of industrial chemicals.
The workshop included an IT Modelling Fair at the end of the first day, where some of the participants demonstrated exposure modelling tools and offered attendees some hands-on experience.
Workshop participants agreed on a number of general principles of best practice in environmental exposure modelling, and some recommendations were identified for practical steps towards improving the use and application of models. These are captured in the workshop report.
This report will be of interest to academic researchers, industrial environmental fate assessors, and regulatory bodies involved in chemical risk assessment.
Assessing environmental exposure of chemicals is a challenging but critical part of assessing environmental risk. While there has been a great deal of resource directed towards activities aimed at advancing the use and application of exposure models, this ECETOC workshop provided the opportunity to review the recent advances in exposure models, with a particular focus on the following key themes:
Quantification of uncertainties
Identification of synergies across the different industry sectors and regulatory bodies
Applicability domain challenges
Chemical mixtures
Non-chemical stressors
Both regulatory and research-oriented models were considered within focused syndicate sessions dedicated to various categories of industrial chemicals.
The workshop included an IT Modelling Fair at the end of the first day, where some of the participants demonstrated exposure modelling tools and offered attendees some hands-on experience.
Workshop participants agreed on a number of general principles of best practice in environmental exposure modelling, and some recommendations were identified for practical steps towards improving the use and application of models. These are captured in the workshop report.
This report will be of interest to academic researchers, industrial environmental fate assessors, and regulatory bodies involved in chemical risk assessment.
2011
Exposure in the aquatic environment. ECETOC Workshop: Combined Exposure to Chemicals. Technical Report
no. Workshop Report No. 22, 2011, ISSN: 2078-7219-22.
Abstract | Links | Tags: 2011, ECETOC, Public Report
@techreport{2011EcetocExposure,
title = {Exposure in the aquatic environment. ECETOC Workshop: Combined Exposure to Chemicals.},
url = {https://www.ecetoc.org/publication/workshop-report-22-workshop-on-combined-exposure-to-chemicals/, Workshop Page
https://www.ecetoc.org/wp-content/uploads/2014/08/ECETOC_WR_22._Combined_exposure_to_chemicals.pdf, Workshop Slides},
issn = {2078-7219-22},
year = {2011},
date = {2011-07-11},
urldate = {2011-07-11},
number = {Workshop Report No. 22},
abstract = {In the last 10 years, there has been a significant amount of research into the toxicology of mixtures and co-exposure, which has genuinely increased our understanding. Participants at the workshop generally agreed that the WHO/IPCS framework provides a useful tool for risk assessment of combined exposure to multiple chemicals from multiple sources. A suitable problem formulation at the outset of any risk assessment of combined exposures to multiple chemicals was thought to be a fundamental first step.
There was overall recognition that according to available evidence, in practice, the toxicity of mixtures in the environment is often dominated by a few of their components, and that these can be identified by available approaches. In this regard, where relevant data are available, the Maximum Cumulative Ratio approach is a useful tool for both human health and environmental risk assessments.
The current state of knowledge shows that synergy (exceeding additive effects) is rare and appears to be toxicologically significant only at doses at which there is significant toxicity of one or more of the individual components in the combination. The available data indicate that synergy does not normally occur at environmental concentrations of man-made chemicals. For chemicals that have different modes of action, there is currently very little data to support the occurrence of combination effects below their individual predicted no-effect levels. However, in the absence of information on mode of action, dose / concentration addition can be used as the conservative default.
The discussion at the workshop identified a number of areas that require further research, such as better understanding of mode of action, improved methodologies of exposure assessment including assimilation of better databases and data processing methods. The threshold of toxicological concern approach and non-testing methods were suggested as potentially useful tools that also need further development for use in this context.
In recent years, there has been growing public perception and concern about the possibility of “cocktail effects” of chemicals at very low doses of the single substances (i.e. below levels deemed to be safe for humans and the environment) which are generally not taken into account in regulatory risk assessment. The current evidence offers little support for this; although some of the workshop participants were of the opinion that the current knowledge on combined exposure and effects was too limited to allow such a conclusion. It is important that combined exposures be considered in risk assessment practice – through the use of science-based, targeted and pragmatic tiered approaches. Such approaches should allow identification of any combinations which may require priority attention.
Whilst recognising the importance of addressing the potential risk of combined exposures to chemicals, this should perhaps be seen in light of the various other scientific areas that are important for protecting and improving human health and the environment. However, some workshop participants felt that this view is a general one, which does not only concern the issue of combined exposure and effects of chemicals. Overall though, the use of a tiered approach is strongly recommended to ensure optimum use of resources.},
keywords = {2011, ECETOC, Public Report},
pubstate = {published},
tppubtype = {techreport}
}
In the last 10 years, there has been a significant amount of research into the toxicology of mixtures and co-exposure, which has genuinely increased our understanding. Participants at the workshop generally agreed that the WHO/IPCS framework provides a useful tool for risk assessment of combined exposure to multiple chemicals from multiple sources. A suitable problem formulation at the outset of any risk assessment of combined exposures to multiple chemicals was thought to be a fundamental first step.
There was overall recognition that according to available evidence, in practice, the toxicity of mixtures in the environment is often dominated by a few of their components, and that these can be identified by available approaches. In this regard, where relevant data are available, the Maximum Cumulative Ratio approach is a useful tool for both human health and environmental risk assessments.
The current state of knowledge shows that synergy (exceeding additive effects) is rare and appears to be toxicologically significant only at doses at which there is significant toxicity of one or more of the individual components in the combination. The available data indicate that synergy does not normally occur at environmental concentrations of man-made chemicals. For chemicals that have different modes of action, there is currently very little data to support the occurrence of combination effects below their individual predicted no-effect levels. However, in the absence of information on mode of action, dose / concentration addition can be used as the conservative default.
The discussion at the workshop identified a number of areas that require further research, such as better understanding of mode of action, improved methodologies of exposure assessment including assimilation of better databases and data processing methods. The threshold of toxicological concern approach and non-testing methods were suggested as potentially useful tools that also need further development for use in this context.
In recent years, there has been growing public perception and concern about the possibility of “cocktail effects” of chemicals at very low doses of the single substances (i.e. below levels deemed to be safe for humans and the environment) which are generally not taken into account in regulatory risk assessment. The current evidence offers little support for this; although some of the workshop participants were of the opinion that the current knowledge on combined exposure and effects was too limited to allow such a conclusion. It is important that combined exposures be considered in risk assessment practice – through the use of science-based, targeted and pragmatic tiered approaches. Such approaches should allow identification of any combinations which may require priority attention.
Whilst recognising the importance of addressing the potential risk of combined exposures to chemicals, this should perhaps be seen in light of the various other scientific areas that are important for protecting and improving human health and the environment. However, some workshop participants felt that this view is a general one, which does not only concern the issue of combined exposure and effects of chemicals. Overall though, the use of a tiered approach is strongly recommended to ensure optimum use of resources.
There was overall recognition that according to available evidence, in practice, the toxicity of mixtures in the environment is often dominated by a few of their components, and that these can be identified by available approaches. In this regard, where relevant data are available, the Maximum Cumulative Ratio approach is a useful tool for both human health and environmental risk assessments.
The current state of knowledge shows that synergy (exceeding additive effects) is rare and appears to be toxicologically significant only at doses at which there is significant toxicity of one or more of the individual components in the combination. The available data indicate that synergy does not normally occur at environmental concentrations of man-made chemicals. For chemicals that have different modes of action, there is currently very little data to support the occurrence of combination effects below their individual predicted no-effect levels. However, in the absence of information on mode of action, dose / concentration addition can be used as the conservative default.
The discussion at the workshop identified a number of areas that require further research, such as better understanding of mode of action, improved methodologies of exposure assessment including assimilation of better databases and data processing methods. The threshold of toxicological concern approach and non-testing methods were suggested as potentially useful tools that also need further development for use in this context.
In recent years, there has been growing public perception and concern about the possibility of “cocktail effects” of chemicals at very low doses of the single substances (i.e. below levels deemed to be safe for humans and the environment) which are generally not taken into account in regulatory risk assessment. The current evidence offers little support for this; although some of the workshop participants were of the opinion that the current knowledge on combined exposure and effects was too limited to allow such a conclusion. It is important that combined exposures be considered in risk assessment practice – through the use of science-based, targeted and pragmatic tiered approaches. Such approaches should allow identification of any combinations which may require priority attention.
Whilst recognising the importance of addressing the potential risk of combined exposures to chemicals, this should perhaps be seen in light of the various other scientific areas that are important for protecting and improving human health and the environment. However, some workshop participants felt that this view is a general one, which does not only concern the issue of combined exposure and effects of chemicals. Overall though, the use of a tiered approach is strongly recommended to ensure optimum use of resources.
2007
Brown, C.; Alix, A.; Alonso-Prados, J-l.; Auteri, D.; Gril, J-J.; Hiederer, R.; Holmes, C.M.; Huber, A.; de Jong, F.; Liess, M.; Loutseti, S.; Mackay, N.; Maier, W-M.; Maund, S.; Pais, C.; Reinert, M.; Russell, M.; Schad, T.; Stadler, M.; Streloke, M.; Styczen, M.; van de Zande, J.
Landscape and Mitigation Factors in Aquatic Ecological Risk Assessment. Volume 1. Extended Summary and Recommendations. Technical Report
no. 1, 2007.
Links | Tags: 2007, Public Report
@techreport{FOCUS1,
title = {Landscape and Mitigation Factors in Aquatic Ecological Risk Assessment. Volume 1. Extended Summary and Recommendations.},
author = {Brown, C. and Alix, A. and Alonso-Prados, J-l. and Auteri, D. and Gril, J-J. and Hiederer, R. and Holmes, C.M. and Huber, A. and de Jong, F. and Liess, M. and Loutseti, S. and Mackay, N. and Maier, W-M. and Maund, S. and Pais, C. and Reinert, M. and Russell, M. and Schad, T. and Stadler, M. and Streloke, M. and Styczen, M. and van de Zande, J.},
url = {https://esdac.jrc.ec.europa.eu/projects/focus-landscape-mitigation, Report webpage
https://esdac.jrc.ec.europa.eu/public_path/projects_data/focus/lm/docs/FOCUS%20LM%20Volume%201%20v2_0.pdf, FOCUS volume 1},
year = {2007},
date = {2007-09-01},
urldate = {2007-09-01},
number = {1},
keywords = {2007, Public Report},
pubstate = {published},
tppubtype = {techreport}
}
Brown, C.; Alix, A.; Alonso-Prados, J-L.; Auteri, D.; Gril, J-J.; Hiederer, R.; Holmes, C.M.; Huber, A.; de Jong, F.; Liess, M.; Loutseti, S.; Mackay, N.; Maier, W-M.; Maund, S.; Pais, C.; Reinert, M.; Russell, M.; Schad, T.; Stadler, M.; Streloke, M.; Styczen, M.; van de Zande, J.
Landscape and Mitigation Factors in Aquatic Ecological Risk Assessment. Volume 2. Detailed Technical Reviews. Technical Report
no. 2, 2007.
Links | Tags: 2007, Public Report
@techreport{FOCUS2,
title = {Landscape and Mitigation Factors in Aquatic Ecological Risk Assessment. Volume 2. Detailed Technical Reviews.},
author = {Brown, C. and Alix, A. and Alonso-Prados, J-L. and Auteri, D. and Gril, J-J. and Hiederer, R. and Holmes, C.M. and Huber, A. and de Jong, F. and Liess, M. and Loutseti, S. and Mackay, N. and Maier, W-M. and Maund, S. and Pais, C. and Reinert, M. and Russell, M. and Schad, T. and Stadler, M. and Streloke, M. and Styczen, M. and van de Zande, J.},
url = {https://esdac.jrc.ec.europa.eu/projects/focus-landscape-mitigation, Report webpage
https://esdac.jrc.ec.europa.eu/public_path/projects_data/focus/lm/docs/FOCUS%20LM%20volume%202%20v2_0.pdf, FOCUS volume 2},
year = {2007},
date = {2007-09-01},
urldate = {2007-09-01},
number = {2},
keywords = {2007, Public Report},
pubstate = {published},
tppubtype = {techreport}
}
2006
Brown, C.D.; Beulke, S.; Biggs, J.; Holmes, C.M.; Maltby, L.; van Beinum, W.; Williams, R.; Yallop, M.L.
Assessing the impact of agricultural pesticides in the environment (phase II). Technical Report
Environment Agency 2006, ISBN: 978-1-84432-683-9.
Links | Tags: 2006, Environment Agency, Public Report
@techreport{2006EnvironAgency,
title = {Assessing the impact of agricultural pesticides in the environment (phase II).},
author = {Brown, C.D. and Beulke, S. and Biggs, J. and Holmes, C.M. and Maltby, L. and van Beinum, W. and Williams, R. and Yallop, M.L.},
url = {http://ea-lit.freshwaterlife.org/archive/ealit:4775/OBJ/12286_ca_object_representations_media_546_original.pdf, View Report},
isbn = {978-1-84432-683-9},
year = {2006},
date = {2006-12-01},
urldate = {2006-12-01},
institution = {Environment Agency},
keywords = {2006, Environment Agency, Public Report},
pubstate = {published},
tppubtype = {techreport}
}